NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Curcumin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
ARandrogen receptor367Prostate CancerLNCaP----Result shows the significant reduction of AR expression in LNCaP cells treated with curcumin.12239622
BCL2B-cell CLL/lymphoma 2596Prostate CancerDU-145----After treating the DU-145 cells with 50 mM curcumin, results indicate that curcumin downregulated the expression of Bcl-2.11753638
BCL2B-cell CLL/lymphoma 2596Prostate CancerLNCaP----After treating the LNCaP cells with 50 mM curcumin, results indicate that curcumin downregulated the expression of Bcl-2.11753638
BCL2L1BCL2-like 1598Prostate CancerDU-145----After treating the DU-145 cells with 50 mM curcumin, results indicate that curcumin downregulated the expression of Bcl-xL.11753638
BCL2L1BCL2-like 1598Prostate CancerLNCaP----After treating the LNCaP cells with 50 mM curcumin, results indicate that curcumin downregulated the expression of Bcl-xL.11753638
CASP3caspase 3, apoptosis-related cysteine peptidase836Prostate CancerDU-145----100 uM curcumin activated the procaspase-3 in DU145 cells.11753638
CASP3caspase 3, apoptosis-related cysteine peptidase836Prostate CancerLNCaP----100 uM curcumin activated the procaspase-3 in LNCaP cells.11753638
CASP3caspase 3, apoptosis-related cysteine peptidase836Prostate CancerDU-145----Curcumin (50 uM) was found to activate caspase-3 in DU145 cells.11753638
CASP3caspase 3, apoptosis-related cysteine peptidase836Prostate CancerLNCaP----Curcumin (50 uM) was found to activate caspase-3 in LNCaP cells.11753638
CASP8caspase 8, apoptosis-related cysteine peptidase841Prostate CancerDU-145----100 uM curcumin activated the procaspase-8 in DU145 cells.11753638
CASP8caspase 8, apoptosis-related cysteine peptidase841Prostate CancerLNCaP----100 uM curcumin activated the procaspase-8 in LNCaP cells.11753638
CASP8caspase 8, apoptosis-related cysteine peptidase841Prostate CancerDU-145----Curcumin (50 uM) was found to activate caspase-8 in DU145 cells.11753638
CASP8caspase 8, apoptosis-related cysteine peptidase841Prostate CancerLNCaP----Curcumin (50 uM) was found to activate caspase-8 in LNCaP cells.11753638
COX-2cytochrome c oxidase subunit II4513Colon CancerHT-29----Curcumin markedly inhibited COX-2 mRNA expression even at the 5 mM concentration after 6 h of treatment. Inhibition in COX-2 mRNA expression was also observed at higher concentrations (10-75 mM) of curcumin after 6 h of treatment. Maximum inhibition in COX-2 mRNA was observed at 75 mM curcumin.11566484
DUSP10dual specificity phosphatase 1011221Prostrate CarcinomaLAPC-4----Prostrate cancer cell line LAPC-4 retain the ability to up-regulate MKP5 in response to curcumin.17151092
DUSP10dual specificity phosphatase 1011221Prostate CancerLNCaP----Prostrate cancer cell line LNCaP retain the ability to up-regulate MKP5 in response to curcumin.17151092
DUSP10dual specificity phosphatase 1011221Prostate CancerDU-145----Prostrate cancer cell lines DU 145, retain the ability to up-regulate MKP5 in response to curcumin and that curcumin reduced p38-mediated, but not NFkB-mediated, pro-inflammatory signaling by T+1 in DU 145 cell.17151092
DUSP10dual specificity phosphatase 1011221Prostate CancerPC-3----Prostrate cancer cell lines PC-3 retain the ability to up-regulate MKP5 in response to curcumin.17151092
JUNjun proto-oncogene3725Prostate CancerDU-145----Curcumin completely suppressed AP-1 in DU145 cells at around 50 µM.11753638
JUNjun proto-oncogene3725Prostate CancerLNCaP----Transcriptional activities of AP-1 and NF-kB were significantly decreased by the treatment with maximum non-toxic doses of curcumin12239622
JUNjun proto-oncogene3725Prostate CancerPC-3----Transcriptional activities of AP-1 and NF-kB were significantly decreased by the treatment with maximum non-toxic doses of curcumin12239622
JUNjun proto-oncogene3725Human promyelocytic leukemiaHL-60----When the HL-60 cells were preincubated with various concentrations of curcumin, TPA induced activation of AP-1 was inhibited in a concentration dependent manner. An almost complete inhibition of AP-1 activation was achieved with curcumin at a concentration as low as 1 µM.12297018
MMP14matrix metallopeptidase 14 (membrane-inserted)4323Murine melanoma B16(F10)----On treatment of B16F10 cells with curcumin (15 mM for 15 days), MT1-MMP expression was reduced virtually to background levels when compared with control B16F10 cells. MT1-MMP expression remained at background levels even after 28 days of drug withdrawa.15219947
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)4313Murine melanoma B16(F10)----Gelatin zymography of serum free culture medium of control (untreated) B16F10 showed presence of pro (72 kDa) and active (68 kDa)MMP-2.On treatment with curcumin(15mM),MMP-2 activity (both pro and active) was reduced after 3 - 6 days. Reduction of MMP-2 activity could be important reasons for anti-metastatic property of curcumin.15219947
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Prostate CancerLNCaP----Curcumin completely suppressed TNF induced NF-kB activation in a dose-dependent manner, with maximum suppression occurring at around 25 µM.11753638
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Prostate CancerDU-145----Curcumin completely suppressed TNF induced NF-kB activation in a dose-dependent manner, with maximum suppression occurring at around 75 µM.11753638
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Prostate CancerLNCaP----Results demonstrate that LNCaP cells express constitutively active NF-nB, which is inhibited by curcumin.15252141
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Human promyelocytic leukemiaHL-60----TPA-induced NF-kappaB activation was significantly inhibited when the HL-60 cells were pretreated with 5 µM or 10 µM curcumin, while no significant effect was observed at 1 µM.12297018
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Prostate CancerPC-3----Transcriptional activitie of NF-kB were significantly decreased by the treatment with maximum non-toxic doses of curcumin12239622
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Prostate CancerLNCaP----Transcriptional activities of AP-1 and NF-kB were significantly decreased by the treatment with maximum non-toxic doses of curcumin12239622
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 4792Prostate CancerLNCaP----Phosphorylation of I-kappa-B-alpha was partially to completely inhibited by curcumin at 12.5 Amol/L after 4- and 20-hour treatment.15252141
PARP1poly (ADP-ribose) polymerase 1142Prostate CancerDU-145----Curcumin also induced caspase-dependent cleavage of PARP in a time-dependent manner.11753638
PARP1poly (ADP-ribose) polymerase 1142Prostate CancerLNCaP----Curcumin also induced caspase-dependent cleavage of PARP in a time-dependent manner.11753638
PTK2PTK2 protein tyrosine kinase 25747Murine melanoma B16(F10)----On treatment of B16F10 cells with curcumin (15 mM for 15 days), FAK expression was reduced virtually to background levels when compared with control B16F10 cells. FAK expression remained at background levels even after 28 days of drug withdrawal.15219947

 






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