NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Cucurbitacin B

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

signal transducer and activator of transcription 3 (acute-phase response factor)

Pancreatic Cancer

PANC-1

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the activation of STAT3 was markedly inhibited by 4 h treatment with cucurbitacin B.

signal transducer and activator of transcription 3 (acute-phase response factor)

Lung adenocarcinoma

A549

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Cuc B treatment suppressed P-STAT3.

signal transducer and activator of transcription 3 (acute-phase response factor)

Epidermoid carcinoma of larynx

Hep-2

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Measuring the modulation of regulators in the cell cycle, apoptosis and signal transductions by Western blot analysis showed that the effect of cucurbitacin B was due to suppression of the expression of p-STAT3.

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.