NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Cucurbitacin B

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BCL2B-cell CLL/lymphoma 2596Epidermoid carcinoma of larynxHep-2----Measuring the modulation of regulators in the cell cycle, apoptosis and signal transductions by Western blot analysis showed that the effect of cucurbitacin B was due to suppression of the expression of Bcl-2.18309509
BCL2L1BCL2-like 1598Pancreatic CancerPANC-1----The drug also decreased the protein level of the antiapoptotic Bcl-XL protein over 24 h.19605406
CASP3caspase 3, apoptosis-related cysteine peptidase836Pancreatic CancerPANC-1----The drug increased the proapoptotic caspase-3 over 24 h.19605406
CASP9caspase 9, apoptosis-related cysteine peptidase842Pancreatic CancerPANC-1----The drug increased the proapoptotic caspase-9 enzyme level associated with PARP cleavage over 24 h.19605406
CCNB1cyclin B1891Epidermoid carcinoma of larynxHep-2----Measuring the modulation of regulators in the cell cycle, apoptosis and signal transductions by Western blot analysis showed that the effect of cucurbitacin B was due to suppression of the expression of cyclin B1.18309509
CCNB1cyclin B1891Pancreatic CancerPANC-1----The cell cycle regulators cyclin B1 decreased after 24 h exposure to cucurbitacin .19605406
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Pancreatic CancerPANC-1----kinase inhibitor p21WAF1, which is associated with cell cycle arrest and apoptosis, was increased in a time-dependent manne.19605406
CycACyclin A39340Pancreatic CancerPANC-1----The cell cycle regulators cyclin A decreased after 24 h exposure to cucurbitacin .19605406
JAK2Janus kinase 23717Lung adenocarcinomaA549----Cuc B treatment suppressed P-JAK2.15735720
JAK2Janus kinase 23717Pancreatic CancerPANC-1----the activation of JAK2 was markedly inhibited by 4 h treatment with cucurbitacin B.19605406
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)6774Pancreatic CancerPANC-1----the activation of STAT3 was markedly inhibited by 4 h treatment with cucurbitacin B.19605406
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)6774Lung adenocarcinomaA549----Cuc B treatment suppressed P-STAT3.15735720
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)6774Epidermoid carcinoma of larynxHep-2----Measuring the modulation of regulators in the cell cycle, apoptosis and signal transductions by Western blot analysis showed that the effect of cucurbitacin B was due to suppression of the expression of p-STAT3.18309509
STAT5Bsignal transducer and activator of transcription 5B6777Pancreatic CancerPANC-1----the activation of STAT5 was markedly inhibited by 4 h treatment with cucurbitacin B.19605406

 






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