NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Costunolide

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP3caspase 3, apoptosis-related cysteine peptidase836Breast CarcinomaMDA-MB-231----Costunolide suppresses cell growth in MDA-MB-231 breast cancer cells through extrinsic-apoptotic pathway related with activation of Caspase-3.22147197
CASP8caspase 8, apoptosis-related cysteine peptidase841Breast CarcinomaMDA-MB-231----costunolide suppresses cell growth in MDA-MB-231 breast cancer cells through extrinsic-apoptotic pathway related with activation of caspase-8.22147197
CCNB1cyclin B1891Breast CarcinomaMDA-MB-231----Costunolide treatment resulted in a decrease in the levels of central protein for G2/M transition such as Cdc2 and cyclin B.22147197
CDK1cyclin-dependent kinase 1983Breast CarcinomaMDA-MB-231----Costunolide treatment resulted in a decrease in the levels of central protein for G2/M transition such as Cdc2.22147197
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Breast CarcinomaMDA-MB-231----Costunolide-induced G2/M cell cycle arrest is associated with upregulation of p21WAF1 in MDA-MB-231 cells through a p53-independent pathway.22147197
FasTNF receptor superfamily, member 6355Breast CarcinomaMDA-MB-231----costunolide suppresses cell growth in MDA-MB-231 breast cancer cells through extrinsic-apoptotic pathway related with activation of Fas-death receptor.22147197
PARP1poly (ADP-ribose) polymerase 1142Breast CarcinomaMDA-MB-231----we found that the cleavage of PARP was inhibited after 24-h incubation while costunolide alone still shows the degradation of PAR.22147197

 






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