NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Corosolic acid

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581Cervix AdenocarcinomaHeLa----HeLa cells resulted in an increased level of Bax expression in a time dependent manner. Results suggest that CRA-induced apoptosis in HeLa cells via alteration of the Bax/Bcl-2 ratio.19457606
CASP3caspase 3, apoptosis-related cysteine peptidase836Cervix AdenocarcinomaHeLa----Caspase-3 activity increased 9.6-fold after 12 h and 14.9-fold after 24 h treatment.19457606
CASP8caspase 8, apoptosis-related cysteine peptidase841Cervix AdenocarcinomaHeLa----The activities of caspase-8 increased 1.6-fold after 12 h, 2.3-fold after 24 h treatment, respectivel.19457606
CASP9caspase 9, apoptosis-related cysteine peptidase842Cervix AdenocarcinomaHeLa----The activities of caspase-9 increased 2.3-fold after 12 h,3.4-fold after 24 h treatment, respectivel.19457606

 






Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.