NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Butein

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
PARP1poly (ADP-ribose) polymerase 1142Prostate CancerLNCaP----On treatment of LNCaP cells with butein, they found that there was an increase in the protein expression of the 85 KD fragment of PARP, while there was a decrease in the protein expression of full-size PARP (116 KD) protein. And PARP has several cellular functions including DNA recombination and repair, cellular proliferation, apoptosis in ischemic conditions, and necrotic cell deat.22114764

 






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