NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Butein

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Liver Carcinoma SK-HEP-1----Butein at 50 µM might inhibit theNF-kB activity, which is able to involve cell migration and invasion of SK-HEP-1 cells.21770460
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Prostate CancerLNCaP----It was found that treatment with butein on LNCaP cells resulted in an inhibition of NF-kappaBp65. NF-kappaB forms a family of transcription factors that contributes in numerous biological processes, including immune response, inflammation, cell growth, survival, and development.22114764

 






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