NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Betulinic acid

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

cyclin D1

Breast Carcinoma

T-47D

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-

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Betulinic acid induces dose-dependent changes in expression of cyclin D1 gene

cyclin D1

Medulloblastoma

TE-671

-

-

-

-

Betulinic acid induces dose-dependent changes in expression of cyclin D1 gene

cyclin D1

Multiple Myeloma

RPMI-8226

-

-

-

-

Betulinic acid induces dose-dependent changes in expression of cyclin D1 gene

cyclin D1

Neuroblastoma

SK-N-AS

-

-

-

-

Betulinic acid induces dose-dependent changes in expression of cyclin D1 gene

cyclin D1

T cell leukemia

Jurkat E6.1

-

-

-

-

Betulinic acid induces dose-dependent changes in expression of cyclin D1 gene

cyclin D1

Thyroid carcinoma

FTC238

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-

-

-

Betulinic acid induces dose-dependent changes in expression of cyclin D1 gene

cyclin D1

Prostate Cancer

LNCaP

-

-

-

-

Relatively short-term exposure (24 h) to betulinic acid (>10 µmol/L) induced downregulation of cyclin D1, whereas the cyclin-dependent kinase inhibitors p21 and p27 were expressed at low levels in these cells and were not affected by the treatment.

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.