NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Betulinic acid

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

BCL2-associated X protein

Lung adenocarcinoma

A549

-

-

-

-

A significant increase in bax gene expression, was observed when A549 cells were incubated with different concentration of BA.

BCL2-associated X protein

Colon Cancer

HT-29

-

-

-

-

A significant increase in bax gene expression, was observed when HT-29 cells were incubated with different concentration of BA.

B-cell CLL/lymphoma 2

Breast Carcinoma

T-47D

-

-

-

-

Tumor cell lines showed a decrease of bcl-2 expression when incubated with 1 µM or 5 µM betulinic acid for 24 h.

B-cell CLL/lymphoma 2

Medulloblastoma

TE-671

-

-

-

-

Tumor cell lines showed a decrease of bcl-2 expression when incubated with 1 µM or 5 µM betulinic acid for 24 h.

B-cell CLL/lymphoma 2

Multiple Myeloma

RPMI-8226

-

-

-

-

Tumor cell lines showed a decrease of bcl-2 expression when incubated with 1 µM or 5 µM betulinic acid for 24 h.

B-cell CLL/lymphoma 2

Neuroblastoma

SK-N-AS

-

-

-

-

Tumor cell lines showed a decrease of bcl-2 expression when incubated with 1 µM or 5 µM betulinic acid for 24 h.

B-cell CLL/lymphoma 2

T cell leukemia

Jurkat E6.1

-

-

-

-

Tumor cell lines showed a decrease of bcl-2 expression when incubated with 1 µM or 5 µM betulinic acid for 24 h.

B-cell CLL/lymphoma 2

Thyroid carcinoma

FTC238

-

-

-

-

Tumor cell lines showed a decrease of bcl-2 expression when incubated with 1 µM or 5 µM betulinic acid for 24 h.

baculoviral IAP repeat-containing 5a

Prostate Cancer

LNCaP

-

-

-

-

Betulinic acid also induced caspase-dependent PARP cleavage in LNCaP cells, and this was accompanied by decreased expression of the antiapoptotic protein survivin and induction of DNA laddering typically observed in cells undergoing apoptosis.

cyclin D1

Breast Carcinoma

T-47D

-

-

-

-

Betulinic acid induces dose-dependent changes in expression of cyclin D1 gene

cyclin D1

Medulloblastoma

TE-671

-

-

-

-

Betulinic acid induces dose-dependent changes in expression of cyclin D1 gene

cyclin D1

Multiple Myeloma

RPMI-8226

-

-

-

-

Betulinic acid induces dose-dependent changes in expression of cyclin D1 gene

cyclin D1

Neuroblastoma

SK-N-AS

-

-

-

-

Betulinic acid induces dose-dependent changes in expression of cyclin D1 gene

cyclin D1

T cell leukemia

Jurkat E6.1

-

-

-

-

Betulinic acid induces dose-dependent changes in expression of cyclin D1 gene

cyclin D1

Thyroid carcinoma

FTC238

-

-

-

-

Betulinic acid induces dose-dependent changes in expression of cyclin D1 gene

cyclin D1

Prostate Cancer

LNCaP

-

-

-

-

Relatively short-term exposure (24 h) to betulinic acid (>10 µmol/L) induced downregulation of cyclin D1, whereas the cyclin-dependent kinase inhibitors p21 and p27 were expressed at low levels in these cells and were not affected by the treatment.

Sp1 transcription factor

Prostate Cancer

LNCaP

-

-

-

-

Betulinic acid induces proteasome-dependent degradation of Sp1 proteins, which regulate VEGF and survivin expression.

Sp3 transcription factor

Prostate Cancer

LNCaP

-

-

-

-

Betulinic acid induces proteasome-dependent degradation of Sp3 proteins,which regulate VEGF and survivin expression.

Sp4 transcription factor

Prostate Cancer

LNCaP

-

-

-

-

Betulinic acid induces proteasome-dependent degradation of Sp4 proteins, which regulate VEGF and survivin expression.

vascular endothelial growth factor A

Prostate Cancer

LNCaP

-

-

-

-

Betulinic acid decreased expression of the angiogenic protein VEGF.

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.