NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Beta-lapachone

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
JUNjun proto-oncogene3725LeukemiaU-937----TNF induced a 7-fold activation of AP-1 in U937 cells, and this activation was inhibited by b-lapachone in a concentration dependent manner. The beta-lapachone by itself, however, had no effect on AP-1 activation. In addition, this drug blocked not only the AP-1 activation induced by 1 nM TNF but also that induced by higher concentrations of TNF.10075082

 






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