NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Berberine

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
PARP1poly (ADP-ribose) polymerase 1142Colon cancerSW-620----Berberine was shown to result in dose-dependent cleavage of PARP for 12 or 24 h.17673978
PARP1poly (ADP-ribose) polymerase 1142Prostate CancerPC-3----Treatment of PC-3 cells with berberine induces disruption of mitochondrial membrane potential leading to release of apoptogenic factors in cytosols and activation of caspases and PARP.18275980

 






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