NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Berberine

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BCL2B-cell CLL/lymphoma 2596Colon cancerSW-620----Western analysis showed a marked down-regulation in the c-IAP1 protein as well as Bcl-XL and Bcl-2 in berberine treatment SW620 cell.17673978
BCL2L1BCL2-like 1598Colon cancerSW-620----Western analysis showed a marked down-regulation in the c-IAP1 protein as well as Bcl-XL and Bcl-2 in berberine treatment SW620 cell.17673978
BIDBH3 interacting domain death agonist637Colon cancerSW-620----Levels of cleaved BID showed significantly increase to 2.6 fold of control with the treatment of Berberine.17673978
BIRC2baculoviral IAP repeat containing 2329Colon cancerSW-620----Western analysis showed a marked down-regulation in the c-IAP1 protein as well as Bcl-XL and Bcl-2 in berberine treatment SW620 cell.17673978
CASP3caspase 3, apoptosis-related cysteine peptidase836Prostate CancerPC-3----Treatment of PC-3 cells with berberine increases the cleavage of caspase-318275980
CASP9caspase 9, apoptosis-related cysteine peptidase842Prostate CancerPC-3----Treatment of PC-3 cells with berberine increases the cleavage of caspase-9 and PARP dose-dependently while decreases the levels of caspase-9.18275980
CYCScytochrome c54205Colon cancerSW-620----Berberine was shown to result in detectable levels of cytochrome c in the cytosol.17673978
FASLGFas ligand(TNF superfamily, member 6)356Colon cancerSW-620----Berberine was shown to result in increased levels of Fas-L.17673978
MAPK1mitogen-activated protein kinase 15594Colon cancerSW-620----Berberine was shown to result in time-dependent phosphorylation of p38 MAPK.17673978
MAPK8mitogen-activated protein kinase 85599Colon cancerSW-620----Berberine was shown to result in time-dependent phosphorylation of JNK 17673978
PARP1poly (ADP-ribose) polymerase 1142Colon cancerSW-620----Berberine was shown to result in dose-dependent cleavage of PARP for 12 or 24 h.17673978
PARP1poly (ADP-ribose) polymerase 1142Prostate CancerPC-3----Treatment of PC-3 cells with berberine induces disruption of mitochondrial membrane potential leading to release of apoptogenic factors in cytosols and activation of caspases and PARP.18275980

 






Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.