NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Baicalin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581Human promyelocytic leukemiaHL-60----The result of Western Blotting shows that the levels of Bax increased.17352223
BCL2B-cell CLL/lymphoma 2596Human promyelocytic leukemiaHL-60----The result of Western Blotting shows that the levels of Bcl-2 increased.17352223
CASP12caspase 12100506742Human promyelocytic leukemiaHL-60----The result of Western Blotting shows that the levels of caspase-12 increased.17352223
CASP3caspase 3, apoptosis-related cysteine peptidase836Human promyelocytic leukemiaHL-60----Baicalin induced caspase-3 activity and these effects are dose-dependent.17352223
CYCScytochrome c54205Human promyelocytic leukemiaHL-60----Western blot of cytochrome c from total cells, mitochondria and cytosol and indicates that baicalin promoted cytochrome c release from the mitochondria. The result of Western Blotting shows that the levels of Gadd153 increased. The result of Western Blotting shows that the levels of cytochrome c increased.17352223
DDIT3DNA-damage-inducible transcript 31649Human promyelocytic leukemiaHL-60----Induction of Gadd153 is highly responsive to ER stress.Therefore, the association of Gadd153 levels and ROS in HL-60 cells after exposure to baicalin was investigated. The result of Western Blotting shows that the levels of Gadd153 increased.17352223
HSPA5glucose-regulated protein, 78kDa3309Human promyelocytic leukemiaHL-60----The result of Western Blotting shows that the levels of Grp78 increased.17352223

 






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