NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Amygdalin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581Prostate CancerLNCaP----After treatment with amygdalin at concentrations of 0.1mg/ml, 1mg/ml, and 10mg/ml for 24 h on the DU145 cells the level of Bax mRNA was significantly increased to 2.25+0.25 (n=4,p<0.05), 2.42+0.27 (n=4,p<0.05), and 3.64+0.50 (n=4,p<0.05).16880611
BAXBCL2-associated X protein581Prostate CancerDU-145----After treatment with amygdalin at concentrations of 0.1mg/ml, 1mg/ml, and 10mg/ml for 24 h on the DU145 cells, the level of Bax mRNA was significantly increased to 1.08±0.07(n=4,p<0.05),2.07±0.17(n=4,p<0.05),and 2.43±0.15(n=4,p<0.05), respectively.16880611
BCL2B-cell CLL/lymphoma 2596Prostate CancerDU-145----After treatment with amygdalin at concentrations of 0.1mg/ml, 1mg/ml, and 10mg/ml for 24 h on the DU145 cells, the level of Bcl-2 mRNA was significantly decreased to 0.89±0.05 (n=4,p<0.05), 0.69±0.03 (n=4,p<0.05),and 0.21±0.03 (n=4,p<0.05), respectively.16880611
BCL2B-cell CLL/lymphoma 2596Prostate CancerLNCaP----After treatment with amygdalin at concentrations of 0.1mg/ml, 1mg/ml, and 10mg/ml for 24 h on the LNCaP cells, the level of Bcl-2 mRNA was significantly decreased to 0.78±0.20 (n=4,p<0.05), 0.52±0.20 (n=4,p<0.05), and0.48±0.38 (n=4,p<0.05), respectively.16880611

 






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