NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

NPACT

Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

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Compound: amooranin

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

B-cell CLL/lymphoma 2

Colon cancer

SW-620

-

-

-

-

Bcl-2 appeared to be down-regulated by increasing concentrations of amooranin.

BCL2-like 1

Colon cancer

SW-620

-

-

-

-

Bcl-XL appeared to be down-regulated by increasing concentrations of amooranin.

cytochrome c

Colon cancer

SW-620

-

-

-

-

AMR-induced apoptosis was accompanied by redistribution of cytochrome c from mitochondria to cytosol as well as down regulation of Bcl-2 and Bcl-XL proteins in a dose-dependent manner.

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Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.