NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Alpha-Tomatine

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP3caspase 3, apoptosis-related cysteine peptidase836Prostate CancerPC-3----Caspase-3 activity was significantly elevated at the first hour of treatment and progressed to a maximal level (6-fold over vesicle control) after 24 hours of incubation.21541327
CASP8caspase 8, apoptosis-related cysteine peptidase841Prostate CancerPC-3----High levels of caspase 8 persisted over 24 hours of incubation.21541327
CASP9caspase 9, apoptosis-related cysteine peptidase842Prostate CancerPC-3----High levels of caspase 9 persisted over 24 hours of incubation.21541327
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Prostate CancerPC-3----These results showed that a-tomatine inhibits TNF-a-induced NFkB activation by inhibiting nuclear translocation of NF-kB/p50 and NF-kB/p65 in the treated PC-3 cells.21541327

 






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