NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Aloe-emodin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
MAPK1mitogen-activated protein kinase 15594Rat GliomaC6----Compound significantly reduced the level of phospho-ERK in C6 cells, as determined by cell-based ELISA.15747063
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)4313Colorectal cancer WiDr----The activation of MMP-2 was subsequently reduced to the basal levels on incubation with Aloe-emodin, whereas the activation of MMP-9 was brought down by 2.8-fold on treatment with Aloe-emodin22227305
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)4318Colorectal cancer WiDr----The activation of MMP-2 was subsequently reduced to the basal levels on incubation with Aloe-emodin, whereas the activation of MMP-9 was brought down by 2.8-fold on treatment with Aloe-emodin.22227305
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Colorectal cancer WiDr----Aloe-emodin was shown to inhibit the DNA binding activity of NF-kappaB.22227305

 






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