NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Acacetin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
HIF1Ahypoxia inducible factor 13091Ovarian adenocarcinomaOVCAR-3----Acacetin inhibited HIF-1alpha expression by increased HIF-1alpha protein degradation.The half-life of HIF-1alpha was 4.2 min and 5.2 min in OVCAR-3 and A2780 cells, respectively, in the presence of CHX alone, and was decreased to 2 min and 1.4 min, respectively with the treatment of acacetin.21893035
HIF1Ahypoxia inducible factor 13091Ovarian CancerA-2780----Acacetin inhibited HIF-1alphalpha expression by increased HIF-1alpha protein degradation.The half-life of HIF-1alphalpha was 4.2 min and 5.2 min in OVCAR-3 and A2780 cells, respectively, in the presence of CHX alone, and was decreased to 2 min and 1.4 min, respectively with the treatment of acacetin.21893035
HIF1Ahypoxia inducible factor 13091Ovarian carcinomaOVCAR-3----The micro-vessel density was decreased by acacetin treatment to 50% of the control,showing that acacetin inhibited ovarian cancer cells-induced angiogenesis in vivo. Acacetin inhibited the levels of HIF-1alpha in tumor tissue samples21893035

 






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