| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 1026 | Lung adenocarcinoma | A549 | - | - | - | - | Increase in p21/WAF1 protein was apparent at 6 h and reached maximuminduction at 24 h in acacetin treated A549 cells. Moreover, the induction of p21/WAF1 was observed to be in a dose-dependent manner. Based on these data, we suggest that acacetin-mediated cell cycle arrest might operate through the induction of p21/WAF1 protein on a p53-dependent event in A549 cells. | 15246561 |