NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: acacetin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Lung adenocarcinomaA549----Increase in p21/WAF1 protein was apparent at 6 h and reached maximuminduction at 24 h in acacetin treated A549 cells. Moreover, the induction of p21/WAF1 was observed to be in a dose-dependent manner. Based on these data, we suggest that acacetin-mediated cell cycle arrest might operate through the induction of p21/WAF1 protein on a p53-dependent event in A549 cells.15246561

 






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