NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Acacetin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
AKT1v-akt murine thymoma viral oncogene homolog 1207Ovarian adenocarcinomaOVCAR-3----The potential mechanism of acacetin in inhibiting VEGF expression, they showed that acacetin inhibited AKT activation.21893035
AKT1v-akt murine thymoma viral oncogene homolog 1207Ovarian CancerA-2780----The potential mechanism of acacetin in inhibiting VEGF expression, they showed that acacetin inhibited AKT activation.21893035
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Lung adenocarcinomaA549----Increase in p21/WAF1 protein was apparent at 6 h and reached maximuminduction at 24 h in acacetin treated A549 cells. Moreover, the induction of p21/WAF1 was observed to be in a dose-dependent manner. Based on these data, we suggest that acacetin-mediated cell cycle arrest might operate through the induction of p21/WAF1 protein on a p53-dependent event in A549 cells.15246561
HIF1Ahypoxia inducible factor 13091Ovarian adenocarcinomaOVCAR-3----Acacetin inhibited HIF-1alpha expression by increased HIF-1alpha protein degradation.The half-life of HIF-1alpha was 4.2 min and 5.2 min in OVCAR-3 and A2780 cells, respectively, in the presence of CHX alone, and was decreased to 2 min and 1.4 min, respectively with the treatment of acacetin.21893035
HIF1Ahypoxia inducible factor 13091Ovarian CancerA-2780----Acacetin inhibited HIF-1alphalpha expression by increased HIF-1alpha protein degradation.The half-life of HIF-1alphalpha was 4.2 min and 5.2 min in OVCAR-3 and A2780 cells, respectively, in the presence of CHX alone, and was decreased to 2 min and 1.4 min, respectively with the treatment of acacetin.21893035
HIF1Ahypoxia inducible factor 13091Ovarian carcinomaOVCAR-3----The micro-vessel density was decreased by acacetin treatment to 50% of the control,showing that acacetin inhibited ovarian cancer cells-induced angiogenesis in vivo. Acacetin inhibited the levels of HIF-1alpha in tumor tissue samples21893035
TP53tumor protein p537157Lung adenocarcinomaA549----The results showed a marked induction of p53 protein in the acacetin treated cells and a trend of dose-dependent manner. The upregulation of p53 by acacetin started to increase 6 h after being treated with acacetin, and maximum expression was observed at 12 h.15246561
VEGFAvascular endothelial growth factor A7422Ovarian adenocarcinomaOVCAR-3----Acacetin decreased VEGF transcriptional activation to 40% in OVCAR-3 cells, suggesting that this compound has a general effect to inhibit VEGF transcriptional activa-tion in ovarian cancer cells. Acacetin at 10 µM and 20 µM greatly inhibited VEGF expression in OVCAR-3 cells.21893035
VEGFAvascular endothelial growth factor A7422Ovarian CancerA-2780----Acacetin decreased VEGF transcriptional activation to 50% in A2780 cells, suggesting that this compound has a general effect to inhibit VEGF transcriptional activation in ovarian cancer cells.21893035
VEGFAvascular endothelial growth factor A7422Ovarian carcinomaOVCAR-3----Acacetin treatment inhibited tumor growth with 50% decrease of tumor weight when compared to that from the control group, indicating that acacetin suppresses tumor growth through impeding the angiogenesis. Acacetin inhibited the levels of VEGF expression in tumor tissue samples21893035

 






Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.