| LTA4H | leukotriene A4 hydrolase | 4048 | Colon carcinogenesis | HCT116 | - | - | - | - | Results showed that mice fed [6]-gingerol survived significantly longer than those receiving vehicle, implying that tumors grew much slower. At day 49, 11 of the [6]-gingerol-treated mice still had not developed tumors equal to 1 cm3. ELISA data showed that [6]- gingerol-treated tumors exhibited a much lower level of LTB4 production, suggesting that [6]-gingerol inhibits colon tumor formation by suppressing LTA4H activity in vivo | 19531649 |