NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: 6-Gingerol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
APAF1apoptotic peptidase activating factor 1317Epidermoid carcinoma A-431----[6]-Gingerol was found to up-regulate expression of Apaf-1, corroborating evidence of apoptotic cell death. 19481070
BAXBCL2-associated X protein581Epidermoid carcinoma A-431----[6]-Gingerol was found to up-regulate expression of apoptotic gene Bax corroborating evidence of apoptotic cell death. Protein expression analysis of these apoptotic proteins showed similar pattern of results; which further validating the apoptotic potential of [6]-gingerol.19481070
BCL2B-cell CLL/lymphoma 2596Epidermoid carcinoma A-431----[6]-Gingerol was found to down-regulate expression of anti-apoptotic gene Bcl-2 . 19481070
CASP3caspase 3, apoptosis-related cysteine peptidase836Epidermoid carcinoma A-431----[6]-Gingerol was found to up-regulate expression of Caspases-3 corroborating evidence of apoptotic cell death. 19481070
CASP9caspase 9, apoptosis-related cysteine peptidase842Epidermoid carcinoma A-431----[6]-Gingerol was found to up-regulate expression of Caspases-9 corroborating evidence of apoptotic cell death.19481070
CYCScytochrome c54205Epidermoid carcinoma A-431----[6]-Gingerol was found to up-regulate expression Cytochrome c, corroborating evidence of apoptotic cell death. Protein expression analysis of these apoptotic proteins showed similar pattern of results; which further validating the apoptotic potential of [6]-gingerol.19481070
DUSP10dual specificity phosphatase 1011221Prostate CancerDU-145----50 µM [6]-gingerol was also able to up-regulate MKP5 in the prostrate cancer cell line DU 145.17151092
DUSP10dual specificity phosphatase 1011221Prostrate CarcinomaLAPC-4----50 µM [6]-gingerol was also able to up-regulate MKP5 in the prostrate cancer cell line LAPC-4.17151092
DUSP10dual specificity phosphatase 1011221Prostate CancerLNCaP----50 µM [6]-gingerol was also able to up-regulate MKP5 in the prostrate cancer cell line LNCaP.17151092
DUSP10dual specificity phosphatase 1011221Prostate CancerPC-3----50 µM [6]-gingerol was also able to up-regulate MKP5 in the prostrate cancer cell line PC-3.17151092
LTA4Hleukotriene A4 hydrolase4048Colon carcinogenesisHCT116----Results showed that mice fed [6]-gingerol survived significantly longer than those receiving vehicle, implying that tumors grew much slower. At day 49, 11 of the [6]-gingerol-treated mice still had not developed tumors equal to 1 cm3. ELISA data showed that [6]- gingerol-treated tumors exhibited a much lower level of LTB4 production, suggesting that [6]-gingerol inhibits colon tumor formation by suppressing LTA4H activity in vivo19531649
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)4313Breast CarcinomaMDA-MB-231----MMP-2 mRNA expression were decreased by [6]-gingerol treatment. 17683926
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)4318HepatomaHep-3B----MMP-9 mRNA expression were decreased by [6]-gingerol treatment.20521273
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)4318Breast CarcinomaMDA-MB-231----The activity of MMP-9 was suppressed in a dose-dependent manner, but the MMP-2 activity was not significantly changed when HepG2 and Hep3B cells were treated with 6-gingrol (5, 10, 25, and 50 µM),respectively. The inhibitory effect on MMP-9 in hepatoma cells by 6-gingroll may be through the regulation of both uPA and TIMP-1. Analysis with semi-quantitative reverse transcription-PCR showed that the regulation of MMP-9 by 6-gingrol .17683926
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)4318HepatomaHep G2----The activity of MMP-9 was suppressed in a dose-dependent manner, but the MMP-2 activity was not significantly changed when HepG2 and Hep3B cells were treated with 6-gingrol (5, 10, 25, and 50 µM),respectively. The inhibitory effect on MMP-9 in hepatoma cells by 6-gingroll may be through the regulation of both uPA and TIMP-1. Analysis with semi-quantitative reverse transcription-PCR showed that the regulation of MMP-9 by 6-gingrol .20521273
TIMP1TIMP metallopeptidase inhibitor 17076HepatomaHep-3B----The physiological activity of MMP-9 is significantly related to the activity of uPA and TIMPs. The protein level of TIMP-1 in HepG2 and Hep3B cells was increased in a dose-dependent manner along with a gradual increase in the concentrations of 6-gingrol used for 24 h treatment.20521273
TIMP1TIMP metallopeptidase inhibitor 17076HepatomaHep G2----The physiological activity of MMP-9 is significantly related to the activity of uPA and TIMPs. The protein level of TIMP-1 in HepG2 and Hep3B cells was increased in a dose-dependent manner along with a gradual increase in the concentrations of 6-gingrol used for 24 h treatment.20521273

 






Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.