NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: 3,6-Epidioxy-1,10-bisaboladiene

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP3caspase 3, apoptosis-related cysteine peptidase836Human promyelocytic leukemiaHL-60----3,6-Epidioxy-1,10-bisaboladiene activated caspases 3 after 3 h22575162
CASP7caspase 7, apoptosis-related cysteine peptidase840Human promyelocytic leukemiaHL-60----3,6-Epidioxy-1,10-bisaboladiene activated caspases 7 after 3 h22575162
CASP8caspase 8, apoptosis-related cysteine peptidase841Human promyelocytic leukemiaHL-60----3,6-Epidioxy-1,10-bisaboladiene activated caspases 8 after 1 h22575162
CASP9caspase 9, apoptosis-related cysteine peptidase842Human promyelocytic leukemiaHL-60----3,6-Epidioxy-1,10-bisaboladiene activated caspases 9 after 12 h22575162
MAPK1mitogen-activated protein kinase 15594Human promyelocytic leukemiaHL-60----EDBD induced apoptosis via phosphorylation of p38 mitogen-activated protein kinase (MAPK) in HL60 cell.22575162

 






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