| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 5243 | Colorectal Adenocarcinoma | CaCo-2 | - | - | - | - | It was concluded that this methoxyflavone enhanced vinblastine uptake by specifically inhibiting drug efflux via P-gp. This may have potential as agent for reversing multidrug resistance or for recovering the bioavailability of certain drugs.The steady-state uptake of [3H]vinblastine was increased by HMF in a concentration-dependent manner, and the uptakes amounted to 578 ±15.9% of the control, in the presence of 50µM methoxyflavones. | 10734174 |