Compound: 23,24-Dihydrocucurbitacin B

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

CASP3

caspase 3, apoptosis-related cysteine peptidase

Breast Carcinoma

Bcap-37

A significant increase in the activity of caspase-3 was observed since 12 h of DHCB treatment.

caspase 8, apoptosis-related cysteine peptidase

Breast Carcinoma

Bcap-37

Activity of caspase-8 and slowly increased until 18 h of DHCB treatment.

caspase 9, apoptosis-related cysteine peptidase

Breast Carcinoma

Bcap-37

Activity of caspase-9 slowly increased until 18 h of DHCB treatment.

poly (ADP-ribose) polymerase 1

Breast Carcinoma

Bcap-37

Evidence of caspase-3 activation was the cleavage of PARP as investigated by Western blot analysis using a mouse monoclonal antibody.

NPACT

Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase