NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
MAPK1mitogen-activated protein kinase 15594Human Carcinoma xenograftsGLC-82----Results showed that phosphorylation of MAPK time-dependently decreased in MDA-MB-453 cells following exposed to 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone.15703376
MAPK1mitogen-activated protein kinase 15594Liver CarcinomaBEL-7402----Results showed that phosphorylation of MAPK time-dependently decreased in MDA-MB-453 cells following exposed to 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone.15703376
MAPK1mitogen-activated protein kinase 15594Colon CarcinomaHDMEC----This suggested that ON-III has potent inhibitory effect on activation of MAPK in a dose-dependent manner in VEGF-stimulating HDMEC cells after treatment with ON-III for 30 min.15703376
MAPK1mitogen-activated protein kinase 15594Breast CarcinomaMDA-MB-453----This suggested that ON-III has potent inhibitory effect on activation of MAPK in a dose-dependent manner in VEGF-stimulating HDMEC cells after treatment with ON-III for 30 min.19242112
MAPK1mitogen-activated protein kinase 15594Breast CarcinomaMDA-MB-453----This suggested that ON-III has potent inhibitory effect on activation of MAPK in a dose-dependent manner in VEGF-stimulating HDMEC cells after treatment with ON-III for 30 min.19242112

 






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