| BCL2L11 | BCL2-like 11 (apoptosis facilitator) | 10018 | Breast Carcinoma | MDA-MB-453 | - | - | - | - | Treatment with 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone caused an increase in Bim protein levels.The results also revealed that the levels of all three major splicing isoforms—Bim-extra long (EL), Bim-long (L) and Bim-short (S)—were induced after 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone treatment. And Bim upregulation was involved in 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone-induced apoptosis in MDA-MB-453 cells. | 19242112 |