Compound: 18-beta-Glycyrrhetic acid

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

BAX

BCL2-associated X protein

Cervical Cancer

SiHa

Treatment with 25-50 µM 18Beta-glycyrrhetinic acid for 24 h showed an increase in the pro-apoptotic Bax protein.

B-cell CLL/lymphoma 2

Cervical Cancer

SiHa

Treatment with 25-50 µM 18Beta-glycyrrhetinic acid for 24 h showed an reduction in anti-apoptotic Bcl-2 level in SiHa cells.

caspase 3, apoptosis-related cysteine peptidase

Cervical Cancer

SiHa

SiHa cells treated with 10-100 µM 18Beta-glycyrrhetinic acid showed a significant increase in the activation of caspase-3.

cytochrome c

Cervical Cancer

SiHa

Treatment with 25-50 µM 18Beta-glycyrrhetinic acid for 24 h showed an increase in the cytochrome c levels.

NPACT

Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase