NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: (+)-Gallocatechin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
TOP2Atopoisomerase (DNA) II alpha 170kDa7153Human CarcinomaCeHa----Emblica officinalis (E. officinalis) polyphenol fraction (EOP) was found to inhibit the activity of topoisomerase II in Sacchromyces cerviacae mutant cell cultures. Cancer cells have higher topoisomerase II levels. Therefore, inhibition of this enzyme is a likely target for therapeutic intervention and may suppress cell proliferation.12866570
TOP2Atopoisomerase (DNA) II alpha 170kDa7153Dalton'sLymphoma Ascites (DLA)-----Emblica officinalis (E. officinalis) polyphenol fraction (EOP) was found to inhibit the activity of topoisomerase II in Sacchromyces cerviacae mutant cell cultures. Cancer cells have higher topoisomerase II levels. Therefore, inhibition of this enzyme is a likely target for therapeutic intervention and may suppress cell proliferation.12866570

 






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