NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: (+)-Gallocatechin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CDC25Ccell division cycle 25 homolog C (S. pombe)995Human CarcinomaCeHa15 µg/mL.---Emblica officinalis (E. officinalis) polyphenol fraction (EOP) inhibited the activity of cdc25 tyrosine phosphatase, an important enzyme involved in cell cycle regulation. This enzyme is a critical regulator of M phase promoting factor (MPF), which removes inhibitory phosphates in the catalytic domain of p34cdc2 thereby directly controls the entry of cells into M phase.12866570
CDC25Ccell division cycle 25 homolog C (S. pombe)995Dalton'sLymphoma Ascites (DLA)-15 µg/ml---Emblica officinalis (E. officinalis) polyphenol fraction (EOP) inhibited the activity of cdc25 tyrosine phosphatase, an important enzyme involved in cell cycle regulation. This enzyme is a critical regulator of M phase promoting factor (MPF), which removes inhibitory phosphates in the catalytic domain of p34cdc2 thereby directly controls the entry of cells into M phase.12866570

 






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