NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: (-)-Gossypol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BBC3BCL2 binding component 327113Prostate CancerPC-3----PC-3 cells treated with gossypol for 24 and 48 h showed a dose-dependent increase of Puma.18645028
BCL2B-cell CLL/lymphoma 2596Prostate CancerPC-3----Protein expression of Bcl-2 was higher in PC-3 cells.18645028
BCL2L1BCL2-like 1598Prostate CancerPC-3----Protein expression of Bcl-xL was higher in PC-3 cells.18645028
BCL2L11BCL2-like 11 (apoptosis facilitator)10018Prostate CancerPC-3----(-)-Gossypol-treated PC-3 cells showed a decrease of Bim proteins.18645028
MCL1myeloid cell leukemia sequence 1 (BCL2-related)4170Prostate CancerPC-3----PC-3 cells treated with gossypol for 24 and 48 h showed a dose-dependent increase of Mcl-1.18645028
PMAIP1phorbol-12-myristate-13-acetate-induced protein 15366Prostate CancerPC-3----PC-3 cells treated with gossypol for 24 and 48 h showed a dose-dependent increase of Noxa.18645028

 






Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.