NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: (-)-Epicatechin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
COX-1cytochrome c oxidase subunit I4512Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.77.5 µM---It inhibits cyclooxygenase 1 (Cox-1) activity and it is an anti-inflammatory mechanism.Phytochemistry Reviews 1: 369-377, 2002
COX-1cytochrome c oxidase subunit I4512--3.2 µM---Testing of compound was performed in-vivo. Compound is shown have anticancer activity.11962253
COX-2cytochrome c oxidase subunit II4513------Testing of compound was performed in-vivo. Compound is shown have anticancer activity.11962253
NOS2nitric oxide synthase 2, inducible4843Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.7>50 µM---Nitric oxide (NO) synthase (iNOS) and consequently, enhance the generation of NO. Generally, NO is an important signaling molecule, long-term elevated levels of NO, however, have been linked to early steps in carcinogenesis.It cause inhibition of lipopolysaccharide (LPS)-mediated induction of inducible nitric oxide synthase , which is an anti-inflammatory mechanis.Phytochemistry Reviews 1: 369-377, 2002
NQO1NAD(P)H dehydrogenase, quinone 11728Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.7>50 µM---Compound induces the QR activity.Phytochemistry Reviews 1: 369-377, 2002
ODC1ornithine decarboxylase 14953------It is found that 80 g of (-)-Epicatechin in 2 mg of GTP showed 17% of inibition on TPA-induced Epidermal ODC activity.The topical application of 4 µmol of (-)-Epicatechin in 0.2 ml acetone/animal 30 min prior to the topical application of 5 µg TPA in 0.2 ml acetone resulted in the significant inhibition of TPA-induced epidermal ODC activity.1617628

 






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