NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: 9-alpha-Hydroxy-seco-ratiferolide-5-alpha-O-(2-methylbutyrate)

ModelsTargetInhibitory ConcRemarkReference
Mouse 109 murine lung carcinoma xenograft model--When tested in the M109 system at 8 and also at 24 mg/kg/injection (the maximum tolerated dose, MTD), compound was inactive, demonstrating T/C values of 103 and 113%, respectively.10579870
HCT116 human colon tumor xenograft model--In the HCT116 model planted subcutaneously in athymic mice,compound was not found to reach a MTD and was inactive at all doses tested, with 30 mg/kg/injection being the highest dose used.10579870

 






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