NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Purpurin

ModelsTargetInhibitory ConcRemarkReference
hepatic DNA adducts in male C57bl6 mice induced by carcinogen Trp-P-2 NADPH cytochrome P450 reductase-Testing of compound was performed in-vivo in male C57bl6 mice after a single dose of the heterocyclic amine dietary carcinogen Trp-P-2. Purpurin treatment was responsible for dose-dependent induction of NADPH cytochrome P450 reductase12744663
hepatic DNA adducts in male C57bl6 mice induced by carcinogen Trp-P-2 Cytochrome P450-Testing of compound was performed in-vivo in male C57bl6 mice after a single dose of the heterocyclic amine dietary carcinogen Trp-P-2. Purpurin treatment was responsible for dose-dependent induction of cytochrome P450 12744663
hepatic DNA adducts in male C57bl6 mice induced by carcinogen Trp-P-2 CYP2B-Testing of compound was performed in-vivo in male C57bl6 mice after a single dose of the heterocyclic amine dietary carcinogen Trp-P-2. Marker enzyme activities demonstrated clearly that induction by purpurin was nonspecific. CYP2B was very markedly induced12744663
hepatic DNA adducts in male C57bl6 mice induced by carcinogen Trp-P-2 CYP1A2-Testing of compound was performed in-vivo in male C57bl6 mice after a single dose of the heterocyclic amine dietary carcinogen Trp-P-2. Marker enzyme activities demonstrated clearly that induction by purpurin was nonspecific. CYP1A2 was very markedly induced12744663
hepatic DNA adducts in male C57bl6 mice induced by carcinogen Trp-P-2 CYP1A1-Testing of compound was performed in-vivo in male C57bl6 mice after a single dose of the heterocyclic amine dietary carcinogen Trp-P-2. Marker enzyme activities demonstrated clearly that induction by purpurin was nonspecific. CYP1A1 was very markedly induced12744663

 






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