NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Piroxicam

ModelsTargetInhibitory ConcRemarkReference
1,2-Dimethylhydrazine Dihydrochloride Induced Colon Carcinogenesis in Male Sprague-Dawley ratsCaspase-9-Protein expression of caspase was found to reduce significantly after DMH treatment as compared to control and others22369161
1,2-Dimethylhydrazine Dihydrochloride Induced Colon Carcinogenesis in Male Sprague-Dawley ratsCaspase-3-Protein expression of caspase was found to reduce significantly after DMH treatment as compared to control and others22369161
1,2-Dimethylhydrazine Dihydrochloride Induced Colon Carcinogenesis in Male Sprague-Dawley ratsBcl-2-Results illustrated that piroxicam treatment stimulate cytochrome c release by downregulating theBcl-2 (an antiapoptotic protein) expression significantly22369161
1,2-Dimethylhydrazine Dihydrochloride Induced Colon Carcinogenesis in Male Sprague-Dawley ratsBax-The expression of the proapoptotic protein, Bax was shown to be considerably elevated on piroxicam treatment.22369161
1,2-Dimethylhydrazine Dihydrochloride Induced Colon Carcinogenesis in Male Sprague-Dawley ratsApaf-1-Results confirmed that DMH treatment for 6wk led to a significant decline in the protein expression of Apaf-1 in the rat colonic mucosa in comparison to control22369161

 






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