NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Z-Guggulsterone

ModelsTargetInhibitory ConcRemarkReference
DU145-Matrigel plug assay in male nude miceVEGF-R2-Oral gavage of z-guggulsterone to male nude mice implanted with DU145-Matrigel plugs significantly inhibits in vivo angiogenesis as judged by immunohistochemical analyses for angiogenic markers (factor VIII and CD31). z-guggulsterone administration caused a statistically significant decrease in protein levels of VEGF-R2 compared with control mice.18202020
1483 xenograftStat-3-Percentages of terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling-positive cells increased 2.2-fold in 1483 xenografts from mice treated with guggulsterone versus vehicle, indicating that guggulsterone induced apoptosis in this xenografts. A decrease in STAT3 expression of 44.3% in 1483-derived tumors was observed.19762335
UM-22b xenograftStat-3-Percentages of terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling-positive cells increased 2.2-fold in UM-22b xenografts from mice treated with guggulsterone versus vehicle, indicating that guggulsterone induced apoptosis in this xenografts. A decrease in STAT3 expression of 87.3% in UM-22b-derived tumors was observed19762335

 






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