NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Wogonin

ModelsTargetInhibitory ConcRemarkReference
Mice were transplanted with tumor cells S180p-53-After the seven-day treatments by the route of i.v., wogonin (20, 40mg/kg) had significant inhibitory effect on the growth of inoculated S180 in mice. The inhibitory rates was 34.24%. After mice with S180 were treated with wogonin (20,40mg/kg) seven times intravenously,wogonin could increase the levels of p53 mRNA dramatically in a concentration-dependent manner.16755005
Mice were transplanted with tumor cells S180Bcl-2-After the seven-day treatments by the route of i.v., wogonin (20, 40mg/kg) had significant inhibitory effect on the growth of inoculated S180 in mice. The inhibitory rates was 34.24%. After mice with S180 were treated with wogonin (20,40mg/kg) seven times intravenously,wogonin could lower the level of bcl-2 mRNA and bcl-2 protein.16755005
Mice were transplanted with tumor cells S180Bax-After the seven-day treatments by the route of i.v., wogonin (20, 40mg/kg) had significant inhibitory effect on the growth of inoculated S180 in mice. The inhibitory rates was 34.24%.After mice with S180 were treated with wogonin (20,40mg/kg) seven times intravenously,wogonin could increase the levels of bax mRNA and bax protein in a concentration-dependent manner.16755005

 






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