NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Withaferin A

ModelsTargetInhibitory ConcRemarkReference
pancreatic (Panc-1) tumor xenograft 4 to 6-week old nu/nu athymic female mice model--WA shows potential anticancer effect against pancreatic cancer in vivo without significant toxicity.19769945
Human PC-3 prostrate xenografts--After 7 days of treatment one WA-treated tumor (at 4.0 mg/kg) became undetectable, and this mouse remained tumor-free to the end of the experiment. Treatment of human prostate PC-3 xenografts with WA for 24 days resulted in 70% inhibition of tumor growth in nude mice, associated with 56% inhibition of the tumor tissue proteasomal chymotrypsin-like activity.17093135

 






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