NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Ursolic acid

ModelsTargetInhibitory ConcRemarkReference
H22 xenograft modelCaspase-8-Inhibition rate of 52.8% was observed in tumor growth in Ursolic acid treated xenografts. The result of western blot showed that the protein level of Caspase-8 was elevated after treatment with UA21716649
H22 xenograft modelCaspase-3-Inhibition rate of 52.8% was observed in tumor growth in Ursolic acid treated xenografts. The result of western blot showed that the protein level of Caspase-3 was elevated after treatment with UA21716649
R-HepG2 cells were inoculated in female mice--Ursolic acid inhibited the growth of tumor on R-HepG2 - bearing nude mice. The accumulation of AIF in the nucleus became, indicated that Ursolic Acid-induced-cell death in vivo through the AIF pathway.20630652

 






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