NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Scopoletin

ModelsTargetInhibitory ConcRemarkReference
Mice were chronically administered 7,12-dimethylbenz [a] anthracene (DMBA)TIMP-2-The TIMP-2 mRNAexpression was significantly elevated by scopoletin treatment20619141
Mice were chronically administered 7,12-dimethylbenz [a] anthracene (DMBA)Survivin-mRNA expression of survivin was downregulated significantly as revealed by statistical analysis20619141
Mice were chronically administered 7,12-dimethylbenz [a] anthracene (DMBA)Stat-3-Expression of Stat-3 from western blotting and the mRNA expression of Stat-3 were found to be significantly reduced with the doses of scopoletin as compared to control.20619141
Mice were chronically administered 7,12-dimethylbenz [a] anthracene (DMBA)PCNA-From the westren bolt analysis and RT-PCR it was revealed that expression level of PCNA was significantly elevated after prolonged administration of DMBA on skin20619141
Mice were chronically administered 7,12-dimethylbenz [a] anthracene (DMBA)p-53-The p-53 expression was significantly elevated in the scopoletin administered group.20619141
Mice were chronically administered 7,12-dimethylbenz [a] anthracene (DMBA)MMP-2-The MMP-2 mRNAexpression was significantly blocked by scopoletin treatment20619141
Mice were chronically administered 7,12-dimethylbenz [a] anthracene (DMBA)CYPIA1-Western Blot analysis and mRNA quantification showed that scopoletin significantly reduced the CYPIA1 overexpression.20619141
Mice were chronically administered 7,12-dimethylbenz [a] anthracene (DMBA)Cyclin D1-mRNA levels of Cyclin D1 was significantly elevated with the treatment of Scopoletin as compared to controlled group20619141
Mice were chronically administered 7,12-dimethylbenz [a] anthracene (DMBA)c-myc-mRNA levels of c-myc was significantly elevated with the treatment of Scopoletin as compared to controlled group20619141
Mice were chronically administered 7,12-dimethylbenz [a] anthracene (DMBA)Caspase-3-Western Blot analysis and mRNA quantification showed that scopoletin significantly elevated the Caspase-3 expression20619141
Mice were chronically administered 7,12-dimethylbenz [a] anthracene (DMBA)Ahr-Scopoletin significantly reduced mRNA expression level of Ahr20619141

 






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