NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Plumbagin

ModelsTargetInhibitory ConcRemarkReference
Female nude mice BALB/cA-nu (nu/nu)] was induced with MDA-MB-231PI3K (p85)-Tumor growth inhibition was most evident in mice treated with plumbagin at 2 mg/kg/d, where an nearly 70% reduction in tumor size was observed. Decreases of PI3K (p85) regulatory subunit was observed in the tumors of the plumbagin-treated mice in comparison with the tumors of vehicle-treated mice.17172425
Female nude mice BALB/cA-nu (nu/nu)] was induced with MDA-MB-231phospho-mTOR-Tumor growth inhibition was most evident in mice treated with plumbagin at 2 mg/kg/d, where an nearly 70% reduction in tumor size was observed. The levels of phospho-mTOR were lower in the tumors from the plumbagin-treated group when compared with the tumors from vehicle-treated mice.17172425
Female nude mice BALB/cA-nu (nu/nu)] was induced with MDA-MB-231phospho-AKT-Tumor growth inhibition was most evident in mice treated with plumbagin at 2 mg/kg/d, where an nearly 70% reduction in tumor size was observed. Decreases of phospho-AKT was observed in the tumors of the plumbagin-treated mice in comparison with the tumors of vehicle-treated mice.17172425

 






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