NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Nordihydroguaiaretic acid

ModelsTargetInhibitory ConcRemarkReference
MCNeuA breast cancer cells injected subcutaneously into female neuTg miceIGF-1R-Twenty nine days post-implantation, and 16 h following the final administration the autophosphorylation of IGF-1R receptor was reduced in tumors from NDGA-treated mice compared to vehicle-treated controls. Inhibition of signaling by this receptor tyrosine kinase through treatment with NDGA in vivo was associated with a reduced tumor growth rate.16142439
MCNeuA breast cancer cells injected subcutaneously into female neuTg miceHER2/neu-Twenty nine days post-implantation, and 16 h following the final administration the autophosphorylation of HER2/neu receptor was reduced in tumors from NDGA-treated mice compared to vehicle-treated controls. Inhibition of signaling by this receptor tyrosine kinase through treatment with NDGA in vivo was associated with a reduced tumor growth rate.16142439

 






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