NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Myricetin

ModelsTargetInhibitory ConcRemarkReference
SKH-1 hairless mouse skin tumorigenesis modelRaf kinase-Raf kinase is a critical target for myricetin in inhibiting the UVB-induced formation of wrinkles and suppression of type I procollagen and collagen levels in mouse skin.21793847
SKH-1 hairless mouse skin tumorigenesis modelMKK4-Myricetin can bind with MKK4 directly and that it attenuated tumor necrosis factor-alpha (TNF-a)-induced JNK and ERK phosphorylation, AP-1 activation, and VEGFexpression. Myricetin fits easily into the ATP-binding site of MKK4, located between the N- and C-lobes of the kinase domain. 21793847
SKH-1 hairless mouse skin tumorigenesis modelAKT-Myricetin-mediated inactivation of Akt in the UVB response plays a role in regulating UVB-induced carcinogenesis21793847

 






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