NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Licochalcone A

ModelsTargetInhibitory ConcRemarkReference
CT-26 liver metastasis model, syngeneic 6-week-old male BALB/c miceMMP-9-MDM2 also play essential roles in the regulation of cell cycle. Licochalcone A treatment resulted in a dose-dependent decrease in MDM2 protein levels, suggesting that Licochalcone A may induce cell cycle arrest by affecting the levels of MDM2 in gastric cancer cells.20383690
CT-26 liver metastasis model, syngeneic 6-week-old male BALB/c miceiNOS-Perturbations in the expression of proinflammatory mediators, including iNOS, is also found in colon carcinogenesis. LicA treatment (30 mg/kg) also reduced the expression of these enzyme.20383690
CT-26 liver metastasis model, syngeneic 6-week-old male BALB/c miceIkBalpha-Licochalcone A suppresses inflammation by blocking NF-kappaB signal, they determined the degradation of Ik-Balpha in colonic tissues by western blot analysis. Licochalcone A treatment blocked Ik-Balpha degradation in AOM/DSS-treated colonic tissues .20383690
CT-26 liver metastasis model, syngeneic 6-week-old male BALB/c miceCytokines-AOM/DSS treatment significantly increased level of cytokines and Licochalcone A (30 mg/kg) significantly blocked these increases .20383690
CT-26 liver metastasis model, syngeneic 6-week-old male BALB/c miceCOX-2-Perturbations in the expression of proinflammatory mediators, including COX-2, is also found in colon carcinogenesis.Licochalcone A treatment (30 mg/kg) also reduced the expression of these enzyme.20383690
CT-26 liver metastasis model, syngeneic 6-week-old male BALB/c miceBeta-catenin-Since accumulation of activated Beta-catenin in the nucleus is particularly relevant in colon cancer, they determined the expression of Beta-catenin.Licochalcone A treatment decreased nuclear Beta-catenin staining in adenocarcinoma cells.20383690

 






Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.