NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Ferulic acid

ModelsTargetInhibitory ConcRemarkReference
azoxymethane (AOM)-induced colon carcinogenesis in F344 ratsQuinone reductase(QR)-Ferulic acid administration at 100mg/kg dose signifcantly elevated QR activity in the colonic mucosa or liver (P< 0.02, P< 0<01, respectively). It significantly increased the activities of detoxification enzymes GST and QR in the liver and/or colonic mucosa. Thus, such evidence for the activity on the detoxifying enzymes may also be related to the blocking effect of FA on AOM-induced colon carcinogenesis.10893437
azoxymethane (AOM)-induced colon carcinogenesis in F344 ratsGlutathione S-transferase(GST)-GST activity in the liver was signifcantly elevated by gavage of FA at a dose of 100 mg/kg body weight (P< 0.03). It significantly increased the activities of detoxification enzymes GST and QR in the liver and/or colonic mucosa. Thus, such evidence for the activity on the detoxifying enzymes may also be related to the blocking effect of FA on AOM-induced colon carcinogenesis.10893437
TPA induced CD-1 mice--Ferulic acid act as inhibitors of TPA-induced tumor promotion and ornithine decarboxylase activity in mouse skin3139287

 






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