NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: (+)-Gallocatechin

ModelsTargetInhibitory ConcRemarkReference
Dalton'sLymphoma Ascites (DLA)Topoisomerase II-Emblica officinalis (E. officinalis) polyphenol fraction (EOP) was found to inhibit the activity of topoisomerase II in Sacchromyces cerviacae mutant cell cultures. Cancer cells have higher topoisomerase II levels. Therefore, inhibition of this enzyme is a likely target for therapeutic intervention and may suppress cell proliferation.12866570
Dalton'sLymphoma Ascites (DLA)Pyruvate transaminase-Elevated levels of serum glutamate pyruvate transaminase (GPT), in the NDEA administered group were significantly reduced by Emblica officinalis (E. officinalis) polyphenol fraction (EOP) treatment.12866570
Dalton'sLymphoma Ascites (DLA)Glutathione S-transferase(GST)-Elevated levels of liver glutathione S- transferase (GST) level in the NDEA administered group were significantly reduced by EOP treatment.12866570
Dalton'sLymphoma Ascites (DLA)Gamma-glutamyl transpeptidase-Gamma-glutamyl transpeptidase activity was raised to 88.4 ± 16.2 U/l in serum of NDEA treated group was reduced to 48.4 ± 14.8 U/l by EOP treatment.12866570
Dalton'sLymphoma Ascites (DLA)CDC25IC50= 15 µg/mlEmblica officinalis (E. officinalis) polyphenol fraction (EOP) inhibited the activity of cdc25 tyrosine phosphatase, an important enzyme involved in cell cycle regulation. This enzyme is a critical regulator of M phase promoting factor (MPF), which removes inhibitory phosphates in the catalytic domain of p34cdc2 thereby directly controls the entry of cells into M phase.12866570
Dalton'sLymphoma Ascites (DLA)Alkaline phosphatase (ALP)-Elevated levels of serum alkaline phosphatase (ALP) in the NDEA administered group were significantly reduced by EOP treatment.12866570

 






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