NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: aglycon 14-hydroxyhypocretenolide

Cell Lines

Cancer

IC₅₀

EC₅₀

ED₅₀

GI₅₀

References

MCF-7

Breast

1.0±0.2 µM (72 h)

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MCF-7

Breast

0.8±0.2 µM

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MCF-7

Breast

0.7±0.1 µM (48h)

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-

-

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ZR-75-1

Breast

1.0±0.1 µM (72 h)

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-

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ZR-75-1

Breast

0.9±0.2 µM (48h)

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ZR-75-1

Breast

0.6±0.1 µM

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-

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SW-872

Connective tissue

3.1±0.4 µM

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10425121

SW-872

Connective tissue

2.8±0.2 µM (72 h)

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SW-872

Connective tissue

2.2±1.1 µM (48h)

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GTB

Haematopoietic and Lymphoid tissue

0.26±0.04 µM

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HL-60

Haematopoietic and Lymphoid tissue

0.26±0.04 µM

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HEp-2

Head and Neck

1.5±0.3 µM (24h)

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HEp-2

Head and Neck

1.3±0.4 µM (48h)

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HEp-2

Head and Neck

1.1±0.1 µM (72 h)

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OVCAR-3

Ovary

2.1±0.3 µM (48h)

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OVCAR-3

Ovary

1.9±0.4 µM

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OVCAR-3

Ovary

1.8±0.2 µM (72 h)

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A-431

Skin

1.5±0.6 µM

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10425121

A-431

Skin

1.3±0.4 µM (48h)

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10425121

A-431

Skin

0.9±0.2 µM (72 h)

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SK-28

Skin

2.8±0.7 µM

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10425121

SK-28

Skin

2.6±1.1 µM (48h)

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10425121

SK-28

Skin

1.2±0.6 µM (72 h)

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10425121

SK-37

Skin

3.2±0.4 µM

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10425121

SK-37

Skin

2.4±0.6 µM (48h)

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10425121

SK-37

Skin

1.8±0.9 µM (72 h)

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10425121

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.