| Primary information |
|---|
| ID | 1377 |
| Peptide Name | SEQ ID4 |
| Sequence | RSCIDTIPKSECTAFQCKHSMKYRLSFCRKTCGTC |
| Length | 35 |
| Chirality | L |
| N-terminal Modification | None |
| C-terminal Modification | None |
| Chemical Modification | N-acetylation at position 19 |
| Linear/ Cyclic | Linear |
| Nature | Natural |
| Source of Origin | Shk toxin of S.helianthus |
| Target | T Lymphocytes Kv1.3 channels |
| Mechanism of Action | By blocking the potassium channel, Kv1.3 of T lymphocytes |
| In vitro/In vivo | Both |
| Cell Line | Peripheral blood human lymhocytes |
| Inhibition Concentartion | 1 nM |
| In vivo Model | CD18-nullPL/J mice |
| Assay | Enzyme-linked immunosorbent assay (ELISA), HPLC |
| Lethal Dose | NA |
| Combination Therapy | Charybdotoxin (ChTX) |
| Pubmed ID | US 6077680 |
| Year of Publication | 2000 |
| 3-D Structure | NA |
