| Primary information |
|---|
| ID | 1271 |
| Peptide Name | Copolymer 1(Cop 1) |
| Sequence | EKAY |
| Length | 4 |
| Chirality | Mix |
| N-terminal Modification | None |
| C-terminal Modification | None |
| Chemical Modification | None |
| Linear/ Cyclic | Linear |
| Nature | Synthetic |
| Source of Origin | NA (Random copolymer) |
| Target | T-cells |
| Mechanism of Action | Inhibits T cell proliferation in response to graft cells, preventing the secretion of cytokines like interleukin 2 (IL-2) and interferon γ (IFN-γ) |
| In vitro/In vivo | In vivo |
| Cell Line | NA |
| Inhibition Concentartion | NA |
| In vivo Model | BALB/c mice, Lewis rats |
| Assay | Skin Grafts Transplantation, Thyroid graft Transplantation |
| Lethal Dose | NA |
| Combination Therapy | Copolymer 1-related heteropolymers in combination with other immunosuppressive drugs induce a synergistic effect, This is used as copolymer or related hateropolymer |
| Pubmed ID | US 20060276390 A1 |
| Year of Publication | 2006 |
| 3-D Structure | NA |
