Primary information |
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ID | 1269 |
Peptide Name | Copolymer 1(Cop 1) |
Sequence | EKAY |
Length | 4 |
Chirality | L |
N-terminal Modification | None |
C-terminal Modification | None |
Chemical Modification | None |
Linear/ Cyclic | Linear |
Nature | Synthetic |
Source of Origin | NA (Random copolymer) |
Target | T-cells |
Mechanism of Action | Inhibits T cell proliferation in response to graft cells, preventing the secretion of cytokines like interleukin 2 (IL-2) and interferon γ (IFN-γ) |
In vitro/In vivo | In vivo |
Cell Line | NA |
Inhibition Concentartion | NA |
In vivo Model | BALB/c mice, Lewis rats |
Assay | Skin Grafts Transplantation, Thyroid graft Transplantation |
Lethal Dose | NA |
Combination Therapy | Copolymer 1-related heteropolymers in combination with other immunosuppressive drugs induce a synergistic effect, This is used as copolymer or related hateropolymer |
Pubmed ID | US 20060276390 A1 |
Year of Publication | 2006 |
3-D Structure | NA |